One of the most popular diet pills that have been scrutinized for its intense, widespread side effects is Phentermine 37.5 mg. Numerous consumer warnings have been generated to prevent the use of this diet pill as a weight loss method. When used as an OTC diet pill, the side effects of this drug are taken less seriously. This trend is concerning, due to the health concerns that any dosage can generate on a short- and long-term basis. It should be taken as a last resort, but it is best to disregard usage of this drug entirely.
In 1959, Phentermine resin became available in the U.S. and was followed by the introduction of Phentermine Hydrochloride in the 1970s. Previously available under the name Fastin, which was removed from the market in 1998, Phen Hydrochloride became increasingly popular in 1973 when it was combined with Fenfluramine. Known as Fen-Phen, this powerful diet cocktail resulted in numerous cases of heart valve disease and abnormal heart valve findings.
Mechanism of Action
Along with a reduced-calorie diet and exercise, this medication is a legitimate method of weight loss for those who have a severe risk of developing obesity-related health conditions, such as high blood pressure, diabetes, and heart disease. Though it is not known how this medication helps patients lose weight, doctors do know that it is an appetite suppressant that belongs to a class of drugs known as sympathomimetic amines. This dangerous drug class is similar in prototype to well-known amphetamines, which also aid in weight loss.
Dosage and Administration
Phentermine 37.5 is usually prescribed and taken in an oral manner. Dissolving tablets or sustained-release capsules are common. This diet pill should be taken in the lowest effective dosage or as recommended by a physician. Ingesting this medication a few hours after eating breakfast seems to produce adequate results for most patients.
Generally available in the dosage of 37.5 mg in the forms of hydrochloride or HCl, these capsules also include inactive ingredients: monohydrate, lactose, pregelatinized starch, magnesium stearate, colloidal silicon dioxide, and microcrystalline cellulose. The pharmacodynamics of this medication is similar to those of amphetamines in the nature that they utilize the central nervous system, which can lead to an increase in blood pressure. However, elevated blood pressure is not the sole side effect of this medication.
In order to protect consumers and patients, the FDA has released a categorical list of potential side effects of Phentermine 37.5 mg. In essence, it has displayed a large number of serious side effects, which makes this drug dangerous on many levels. Ranging from critical to bothersome, these side effects are commonly experienced:
- PPH (Primary Pulmonary Hypertension): A fatal, yet rare, disease of the lungs.
- Valvular Heart Disease: Effects mitral, aortic, and/or tricuspid valves in individuals who had no prior heart condition.
- Cardiovascular: Palpitation, tachycardia, blood pressure elevation, and ischemic events.
- CNS (Central Nervous System): Restlessness, dizziness, insomnia, headache, psychosis.
- Gastrointestinal: Oral dryness, constipation, diarrhea, unpleasant taste.
- Endocrine: Impotence and changes in libido.
The aforementioned side effects are only a select few of the known characteristics of this drug. As a result of the numerous side effects of this medication and the lack of knowledge pertaining to its interaction with other medications, it is merely recommended for short-term use.
In addition to these common side effects, Phentermine may also cause adverse reactions when used in conjunction with MAOIs (Monoamine Oxidase Inhibitors, Alcohol, Insulin and Oral Hypoglycemic Drugs, and Adrenergic Neuron Blocking Drugs. It may also elicit teratogenic effects on human fetuses, which makes it unsafe to use before and during pregnancy. It is also unknown how this drug may be secreted in breast milk, leading physicians to believe that nursing mothers should avoid the use of prescription diet drugs in general in addition to this one.
Brand Name Variations
The drug is available not just under the brand name, but under other dietary aliases, such as Adipex-P, Oby Cap, Suprenza, T-Diet, and Zantryl. These are common OTC terms that most patients will come across when using the diet pill as a weight loss tool without a prescription. However, the side effects and potential adverse reactions are similar, and may even be intensified, when using OTC forms.
What is Phentermine 37.5 used for?
Phentermine 37.5 is a stimulant drug that causes weight loss through appetite suppression. Paired with exercise and a reduced calorie diet, the medication results in weight loss. Since it is only available via prescription, it is only used to treat severe cases of obesity that have failed more conservative treatment methods.